Objectives: Hypertension is a important cardiovascular risk factors that promotes the development of atrial fibrillation (AF). Electrical heterogeneity and instability have been shown in the atrial conduction of hypertensive patients. P dispersion have been shown to be sensitive and specific noninvasive markers of atrial fibrillation. No study has been reported on the effect of Nebivolol on P dispersion. The objective of the present study is to Nebivolol treatment on the effect of P dispersion in hypertension of patient.

Materials and Methods: The study included 65 patients (mean age 50.6±9.8; 31 males and 34 females) who were found to have essential hypertension. Biochemical parameters of all the patients in the study were analyzed, echocardiographies of all were taken and P dispersion was calculated in the ECG. All cases were put on 5 mg/day Nebivolol treatment. Biochemical parameter analyses, ECO and ECG were repeated in the 6th month.

Results: Six-month Nebivolol treatment markedly reduced P dispersion and homogenized atrial myocardium, which provides a basis for atrial arrhythmias. ©2006, Fırat Üniversitesi, Tıp Fakültesi