The patient is 14 years old male patient with mental retardation, gynecomastia and obesity. Borjeson-Forssman- Lehmann syndrome presumed after the clinical and laboratory studies. Given the ease of expression of X-linked disorders in hemizygous males, the X-chromosome has become an obvious focus for beginning to map and identify genes for syndromal and nonspecific mental retardation. ©2007, Firat University, Medical Faculty