[ Ana Sayfa | Editörler | Danışma Kurulu | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | E-Posta ]
Fırat Tıp Dergisi
2015, Cilt 20, Sayı 3, Sayfa(lar) 133-138
[ Turkish ] [ Tam Metin ] [ PDF ]
The Effect of Administration of Oral Clarithromycin and Tetracycline on Postoperative Adhesion Formation in Rat Uterin Horn Model
Remzi ATILGAN1, Şehmus PALA1, Tuncay KULOĞLU2, Ömer Faruk DOĞAN3, Behzat CAN1, Murat ATILGAN4
1Fırat Üniversitesi, Kadın Hastalıkları ve Doğum ABD, Elazığ, Türkiye
2Fırat Üniversitesi, Histoloji ve Embriyoloji ABD, Elazığ, Türkiye
3Urfa Devlet Hastanesi, Kadın-Doğum Kliniği, Şanlıurfa, Türkiye
4Tarım Bakanlığı, Veteriner Hekim, Elazığ, Türkiye

Objective: To investigate effectiveness of oral clarythromycin and tetracycline on the prevention of postoperative adhesions.

Materials and Methods: A total of 28 Wistar-albino rats were divided into four groups. Group 1: abdomen was opened and closed, Group 2: a 2 cm linear incision was made on the right uterine horn and closed, Group 3: 15 minutes after the administration of oral clarithromycin, a 2 cm incision was made on the right uterine horn and closed, Group 4: 15 minutes after the administration oral tetracycline, a 2 cm incision was made on the right uterine horn and closed. Fifteen days later, a re-laparotomy was performed in all groups. Right uterine horn adhesions were assessed on the basis of macro-morphological characteristics and tissue cross-sections were further examined for the signs of fibrosis, angiogenesis, and VEGF and for MDA scoring. Kruskal-Wallis variance analysis and Mann-Whitney U test were used for statistical analyses.

Results: The extent and strength of adhesions were significantly lower in Group 1, Group 3 and Group 4 as compared to Group 2. Fibrosis and angiogenesis scores were significantly higher in Group 2 than in Group 1, Group 3 and Group 4.

Conclusion: Oral administration of clarithromycin and tetracycline was effective in the prevention of postoperative adhesions.


[ Turkish ] [ Tam Metin ] [ PDF ]
[ Ana Sayfa | Editörler | Danışma Kurulu | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | E-Posta ]