Objective: Staphylococcus aureus can cause severe community and healthcare-related infections such as skin and soft tissue infection, urinary system infection, endocarditis, pneumonia, septic arthritis, osteomyelitis, and sepsis. Also, it has high morbidity and mortality rates. In our study, we aimed to determine the resistance rates of methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) isolates to antimicrobials and to examine the resistance profile of our hospital.

Material and Method: Eight hundred and seventy nine S. aureus samples isolated between 2018 and 2019 were included in the study. The isolates were identified by conventional methods and MALDI-TOF MS (Bio Merieux, France). The antimicrobial susceptibility tests of the isolates were determined by the Kirby-Bauer disc diffusion and Gradient diffusion method as suggested by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guideline.

Results: The average rate of MRSA in the two years was 23.3% and the ratio was 24.2% and 22.3% in 2018 and 2019, respectively. Wound cultures were found to be the most frequently isolated clinical sample. No resistance to vancomycin and linezolid was detected in MRSA and MSSA isolates. The highest resistance rates were detected against penicillin in 98% and 82.8% of MRSA and MSSA strains, respectively.

Conclusion: To know the resistance profiles of S. aureus isolates isolated from patients admitted to our hospital; it will guide the empirical treatment. It will also contribute to the control and management of MRSA with effective infection control measures and selective reporting of antimicrobial susceptibility administration.