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Fırat Tıp Dergisi
2004, Cilt 9, Sayı 3, Sayfa(lar) 075-078
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Age Estimation from Human Skins by Using AgNOR
Aysun BARANSEL ISIR 1, Kemal BAKIR 2, Ramazan UÇAK 2, Hikmet Ergin DÜLGER 1
1 Gaziantep Üniversitesi Tıp Fakültesi Adli Tıp Anabilim Dalı,GAZİANTEP
2 Gaziantep Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, GAZİANTEP

The age estimation of postmortem diagnosis is a considerable problem in forensic issues. For age estimation, numerical methods that are evaluated according to proliferative activity of normal cells are tested. AgNOR was exceptionally applied for estimation of chronological ages of unidentified individuals in this study. Use of this method for forensic purposes is presented as an alternative method to determine the age of an individual. Some difficulties seen in the other methods used in routines tried to overcome.

In this study, mitotic activity was examined by AgNOR method that was based on silver-staining of nucleolus organizer regions (NORs), and avarage proliferative index was obtained. These index datas were related eachother according to age groups.

The study was conducted on 38 postmortem samples (23 males and 15 females) without any tumoral pathology in their past. Samples were divided into four age groups; which were newborns (0-12 months), infants (ages of 1-5), adults (ages of 25-35), and olds (ages of 50 and above). When a brief investigation was performed with AgNOR staining, age-related changes were certainly determined and were found a statistically significant correlation (p<0.01) in AgNOR.

In conclusion, although satisfaction in results was obtained for AgNOR, there was a need for further studies involving more individuals. Especially when the other morphological methods are of limited usefulness, AgNOR might be certainly a useful marker in estimating the age of human skin. ©2004, Fırat Üniversitesi, Tıp Fakültesi

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