Lipoma is the most common mesenchymal neoplasm in the human body. Only 13% of them arise in the head and neck region and most of these ocur subcutaneously in the posterior neck. Rarely, they can develop in the infratemporal fossa, oral cavity,pharynx, larynx and parotid gland.They may rarely become giant masses due to their asymptomatic nature. Althogh the lipomas may appear in all parts of the body, giant lipomas are rarely seen in the cervical region. Differential diagnosis includes many malignant and benign tumors. Total surgical excision is the preferred treatment modality. The average age of affected patients is fifth decade of life. It is 5-10 times more common in males. In this case report, we report a 63 years old male with a giant neck mass with a diameter of 13cm and diagnosed as lipoma after its removal and histopathological examination, and reviewed the literature.